- Daleville Jr/Sr High School
- Damar Charter Academy
- Danville Community High School
- Decatur Central High School
- Decatur Township School for Excellence
- DeKalb High School
- Delphi Community High School
- Delta High School
- Donald E Gavit Middle-High School
- Dugger Union Community School Corp
- East Allen University
- East Central High School
- East Chicago Central High School
- East Noble High School
- Eastbrook High School
- Eastern Greene High School
- Eastern Hancock High School
- Eastern High School
- Eastern High School
- Eastside Junior-Senior High School
- Edgewood High School
- Edinburgh Community High School
- Elkhart Central High School
- Elkhart Christian Academy
- Elkhart Memorial High School
- Elwood Jr-Sr High School
- Eman Schools
- Eminence Jr-Sr High School
- Emmerich Manual High School
- Evansville Day School
- Excel Center - Kokomo
- Excel Center - Lafayette Square
- Excel Center - Lafayette
- Excel Center - Richmond
- Excel Center - Shelbyville
- Excel Center - South Bend
- Excel Center For Adult Learners
- Fairfield Jr-Sr High School
- Faith Christian School
- Fishers Christian Academy
- Fishers High School
- Floyd Central High School
- Forest Park Jr-Sr High School
- Fountain Central High School
- Francis Joseph Reitz High School
- Frankfort Senior High School
- Franklin Central High School
- Franklin Community High School
- Franklin County High School
- Frankton Jr-Sr High School
- Fremont High School
- Frontier Jr-Sr High School