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Clostridioides difficile

What do I need to know about Clostridioides difficile?

Clostridioides difficile (C. difficile or C. diff.), formerly known as Clostridium difficile, is an organism that causes life-threatening diarrhea and inflammation of the colon, known as pseudomembranous colitis. The primary risk factor for a Clostridioides difficile infection (CDI) is overuse of antibiotics. Those who have been recently hospitalized, are in a nursing home, are 65 years or older, or have a weakened immune system are also at increased risk.

old white man looking at prescription pill bottle

CDI is estimated to cause almost half a million illnesses in the United States each year, and an estimated 29,300 deaths.

Individuals are 7 to 10 times more likely to acquire a CDI while taking antibiotics and during the month after. That’s because antibiotics that fight bacterial infections by killing bad germs can also get rid of the good germs that protect the body.

Extended stays in healthcare settings, such as hospitals and nursing homes, increase risk for acquiring a CDI. One in 11 people over age 65, diagnosed with a healthcare-associated CDI, die within one month.

Source: CDC

Transmission can occur:

  • When people touch surfaces that are contaminated with poop from an infected person.
  • When people don’t wash their hands with soap and water.
  • When one healthcare facility fails to notify another when it transfers a patient with C. difficile.
Source: CDC
black woman washing hands

Page last updated/reviewed: September 2024